Delayed Mitosis and Chromatid Fusion
نویسندگان
چکیده
منابع مشابه
PHB2 Protects Sister-Chromatid Cohesion in Mitosis
Cohesion between sister chromatids is essential for proper chromosome segregation in mitosis. In vertebrate mitotic cells, most cohesin is removed from the chromosome arms [1-4], but centromeric cohesin is protected by shugoshin until the onset of anaphase [5]. However, the mechanism of this protection of centromeric cohesion is not well understood. Here, we demonstrate that prohibitin 2 (PHB2)...
متن کاملDegradation of Drosophila PIM regulates sister chromatid separation during mitosis.
Drosophila Pimples (PIM) and Three rows (THR) are required for sister chromatid separation in mitosis. PIM accumulates during interphase and is degraded rapidly during mitosis. This degradation is dependent on a destruction box similar to that of B-type cyclins. Nondegradable PIM with a mutant destruction box can rescue sister chromatid separation in pim mutants but only when expressed at low l...
متن کاملSister Chromatid Segregation during Mitosis in Polyploid Wheat.
HE chromosomes of eukaryotes replicate in a semi-conservative manner (TAYLOR, WOODS and HUGHES 1957; PRESCOTT and BENDER 1963). Utilizing this observation, we have studied the segregation of sister chromatids during mitosis of plant and animal cells (LARK, CONSIGLI and MINOCHA 1966; LARK 1967). Autoradiographic measurements of segregation at the second mitosis following incorporation of radioac...
متن کاملChromatid and Chromosome Type Breakage-Fusion-Bridge Cycles
During the development of disomic additions of rye (Secale cereak L.) chromosomes to wheat (Triticum aestivum L.), two reverse tandem duplications on wheat chromosomes 3D and 4A were isolated. By virtue of their meiotic pairing, the reverse tandem duplications initiated the chromatid type of the breakagefusion-bridge (BFB) cycle. This BFB cycle continued through pollen mitoses and in the early ...
متن کاملCohesion Fatigue Induces Chromatid Separation in Cells Delayed at Metaphase
BACKGROUND Chromosome instability is thought to be a major contributor to cancer malignancy and birth defects. For balanced chromosome segregation in mitosis, kinetochores on sister chromatids bind and pull on microtubules emanating from opposite spindle poles. This tension contributes to the correction of improper kinetochore attachments and is opposed by the cohesin complex that holds the sis...
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ژورنال
عنوان ژورنال: Nature
سال: 1938
ISSN: 0028-0836,1476-4687
DOI: 10.1038/141080a0